Abstract
Decreased physical functioning, fatigue, weight gain and drug induced menopause are common persistent effects of therapy in young mid-life women with breast cancer, and chemotherapy-induced premature menopause has been associated with accelerated bone loss. The weight gain, body composition changes with increasing central adiposity, premature menopause and decreased physical functioning in these young mid-life breast cancer survivors affect their quality of life and potentially increase their long term health risks. Aerobic exercise and home-based walking exercise interventions in women with breast cancer have been shown to moderate or prevent weight gain, improve physical and psychosocial functioning, and improve quality of life. Yet there have been no intervention studies specifically designed to evaluate the effects of resistive exercise on body composition and bone mass in young mid-life breast cancer survivors. The purpose of this pilot study is to evaluate the effect of a progressive walking, resistive exercise intervention on bone mass, weight, body composition, general health, physical functioning, and physical and psychological symptoms in young mid-life women following adjuvant chemotherapy for breast cancer.
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Principal Investigator
M. Tish Knobf
Co-Investigators
Loretta DiPietro
Karl Insogna
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