Abstract
The purpose of the study is to evaluate the effect of a strength training exercise intervention on physical and psychological outcomes in premenopausal women with breast cancer who experience premature induced menopause following adjuvant chemotherapy. Cancer treatment induced menopause is associated with accelerated bone loss, estrogen replacement therapy is generally contraindicated in breast cancer survivors, weight gain is common among premenopausal women who receive adjuvant therapy, walking exercise programs have been shown to moderate weight gain and improve psychosocial functioning and breast cancer survivors are interested in health promoting lifestyle behaviors. Thus, the intervention to be tested in this study has the potential to achieve the positive outcomes of established aerobic exercise programs but also contribute to preservation of bone mass, lean muscle mass and strength. The specific aims are: 1) To evaluate the feasibility and adherence to the exercise intervention; 2) To evaluate the effects of the exercise intervention on physical functioning, lean body mass, weight, metabolism and symptom distress; and 3) To determine the effect of a bone loading exercise intervention on bone remodeling, using biochemical markers. This proposal is a pilot feasibility study designed to provide preliminary data for submission of a larger grant.
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Principal Investigator
M. Tish Knobf
Co-Investigators
Loretta DiPietro
Karl Insogna
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